Historically alternative medicines in the United States receive skepticism based upon limited scientific validations. However, the last two decades have shown a rapid increase in the number of American adults approaching these therapeutic methods. It is predominantly significant to the Chinese immigrants, who retain a strong adherence to their cultural health practices. Conducting a survey to assess the prevalence of their Traditional Chinese Medicine (TCM) use, this study hypothesized that the more integrated Chinese immigrants are in the U.S., the less likely they will be using TCM. A 29-item self-administered questionnaire was conducted with 244 Chinese Americans living in San Francisco. It focused on socio-demographic, TCM utilization, resources and accessibility variables, and was offered to subjects in both English and Chinese translations upon voluntary participation. The study used convenience sampling at 11 local service agencies over a nine-week period in 2009. Multivariate analyses for integration factors, including length of residency in the U.S., were performed by logistic regression. Eighty-percent of the participants used TCM for treating illnesses during the previous two years. Among them, nearly 90% indicated a combined usage with conventional treatments. Taking herbal prescriptions from TCM practitioners was the most frequent modality (53.2%), followed by over-the-counter (OTC) herbal pills (44.8%) for self-medication. In multivariate analyses, factors associated with TCM use were shorter duration of residency in the U.S. (p < 0.01), from Mainland China (p = 0.011), with high school education (p = 0.02), fluent in English speaking (p < 0.01), and practicing Western religions (p = 0.05). TCM utilization is common among Chinese immigrants in San Francisco. Results show that TCM users often visit TCM practitioners and the majority of them also seek conventional health care services. Factors determining their medical behaviors are associated with their integration experience, in which the use of TCM declines over-time living in the U.S. Physicians should better recognize and understand the therapeutic preferences among Chinese populations in offering a proper guidance to their health practices.