Understanding the emotional content and relationship-building techniques in patient/nurse interactions can help improve interactive skills for meaningful cancer care. By examining cancer-related medical interviews, systematic processes of communication can be used to explore the importance of patient/nurse interactions while dealing with illness. This research examines the communicative mechanisms nurses employ as resources for building partnering relationships with patients and offering and providing reassurance to them. By implementing Conversation Analysis (CA), select portions of video-recorded and transcribed oncology interviews can be analyzed. Patient/nurse interactions in the context of cancer communication provide insight into how to transform mere theoretical concepts into meaningful interactions to be applied in everyday cancer care.