High throughput screening involves integration of diverse specialties in order to assay thousands of compounds in search of biological activity for future drug discoveries. The process requires organization and analysis of vast amounts of data, which includes information about the compound libraries, the disease targets, reagents, assay-development and micro well plates. With the advent of web 2 technologies, it is feasible to develop bioinformatics tools for the management and analysis of all these areas of High Throughput Screening experimentation. ChemLife is a web-based bioinformatics system that allows users to manage, access, and analyze the diverse and vast amounts of data produced during HTS, making the process much more efficient, and ensuring its smooth functioning. It allows chemists to create compound libraries, which can be used to track the progress and availability of the compound. Biologists are able to develop and store new assay techniques or use previous assay techniques to do the same. It allows researchers to store experimental data for the assays conducted and track down the results until a lead target is found. To support multiple lab locations and dependencies with other labs, the system also supports staff, vendor, warehouse, sales and report management. ChemLife will help the researchers at BioScience Center, San Diego State University, in laboratory management and data analysis. In contrast to commercial packages, ChemLife is an open-source and extensible solution for online usage. It is a platform that not only provides fixed functionalities but also offers flexibility for future enhancements.