In a profession where the nursing shortage is well known and inevitable despite of vacancy reprieves, understanding determinants of job satisfaction may now be an essential component of retention strategies. Many factors are causing the health care industry to see the potential significant implications of the nursing shortage. Collaboratively creating an environment of empowerment, autonomy, and lower stress, nurses are content and satisfied. In turn, satisfied nurses can continue to deliver safe and quality patient care. The purpose of this study was to understand the relationships among the determinants of job satisfaction. Nurse-manager collaboration, empowerment, autonomy, and subjected job stress were the identified independent variables and job satisfaction was the dependent variable. The following instruments were used to measure the perspective study variables: Collaborative Behavior Scale-B (CBS-B); Conditions of Work Effectiveness Questionnaire-II (CWEQ-II); a subscale from the Index of Work Satisfaction; Subjective Job Stress; and Michigan Organizational Assessment Scale. The hypotheses proposed for the study included: there will be positive relationship between nurse-manager collaboration and job satisfaction; there will be a positive relationship between empowerment and job satisfaction; there will be positive relationship between autonomy and job satisfaction; there will be negative relationships between subjective job stress and job satisfaction; there will be significant relationships among nurse-manager collaboration, empowerment, autonomy, and subjective job stress. The research study was a descriptive correlation study design. A convenience, snowball sample methodology was used. Once correlation was identified, the study variables were further analyzed using multiple regression and dominance analysis. There were significant correlations among the study variables. Empowerment had the strongest correlation to job satisfaction (r = 0.71, p < 0.05). It explained 50% of the variance in job satisfaction (_ = 0.76, p < 0.001). Dominance analysis revealed empowerment is the most importance predicator of job satisfaction (F = 46.57, df = 1, 70; R_ = 0.213). The data supported all hypotheses. A post hoc analysis was conducted to determine if any of the study variables were correlated with nurses' perceptions of unit commitment to patient safety, quality of work, and nurse safety. These three variables were measured with one question on the demographic requesting the respondent to rate each of these variables on a 10-point scale. Several statistically significant correlations were identified. Perception of NMC was highly and significantly correlated to perception of unit's commitment to nurse safety. This validates the desire that safety in nursing practice is affected by how effective the collaboration is between the nurse and the nurse manager. The perception of autonomy was significantly correlated to unit's commitment to patient safety. This may imply that the more the nurse believes that the higher their autonomy (scope-specific decision making power) patient safety increases. These results indicate the relationship between nurses' perceptions of NMC, empowerment, autonomy, SJS, and JS with the nurses' perceptions of the units' commitment to patient safety, quality of work, and nurse safety. This is the first time that such findings have been reported.