In this research, we investigate the fundamental sciences and challenges that need to be addressed in scaling up the production of Organic Solar Cell (OSC) from cleanroom environment to large-scale production. The major focuses of the study, therefore, are the determination of optimized conditions and processes for depositing the photoactive layer, anodic layer, and metal cathodic layer. Along with, this research investigates and solves the engineering and production-scale problems associated with the prototyping system. These consist of improved airbrush system, a new inert gas supply, new masking system for patterned deposition, a syringe pump for controlled flow rate of photoactive and anodic material, and a new digital pressure regulator system.