We've Moved!
Visit SDSU’s new digital collections website at https://digitalcollections.sdsu.edu
Description
This study investigates the influence of Coriolis force on transport and hybridization of DNA molecules and Fluid mixing in compact disk (CD) microfluidic platform where centrifugal force is used as the driving force. While the effect of Coriolis force on fluid flow in CD microfluidic channels has been studied experimentally and numerically only recently, its influence on DNA molecule migration and hybridization and on fluid mixing has not been investigated so far. This study addresses this phenomenon through numerical simulation and demonstrates that for most practical geometrical configurations and angular velocity ranges reported in the literature, the Coriolis force introduces significant qualitative and quantitative spatial variations in the hybridization of DNA molecules, particularly at locations near the periphery. In a particular example investigated here, hybridization was observed to reach steady-state at some locations in about half the time required in the absence of Coriolis force. However, our results further indicate that the time frame for hybridization is so fast (< 1 sec) that the effect due to Coriolis force on the location of hybridization is more important than time of hybridization. Our results indicate that for low viscosity fluids, angular velocities as low as 25 rad/sec could introduce Coriolis force that is as high as at least 25% of the main driving centrifugal force. As for the fluid mixing under microchannel with and without obstacles significant amount of fluid mixing efficiency is observed for both kind of channel, the results demonstrates that at higher omega for channel with obstacle has more mixing efficiency then without obstacles
