In the United States, Colorectal Cancer (CRC) is the 2nd leading cause of cancer-related deaths, affecting both men and women of all race/ethnicities. Preventative measures such as screening have significantly contributed to an overall reduction of incidence and mortality rates; however the underutilization of CRC screening by high at risk populations continue to be a problem in the United States. Previous studies have continuously identified lower CRC screening rates among the uninsured, low income and less educated individuals. Using the most current available data on cancer screening from the National Health Interview Survey 2010, this study assessed up-to-date CRC screening adherence between ethnic/racial groups in order to identify any screening disparities that have historically been present among minority ethnic/racial groups. Understanding barriers to CRC screening among high at risk populations can lead to the development and implementation of culturally sensitive and cost-effective programs that may contribute to the overall reduction of cancer burden in the United States.