This study employed conversation analytic methods to examine the use of humor and laughter by oncology patients in 16 medical interviews. More specifically, the study examines how oncology patients take stances, facilitated by humor and laughter, in the midst of raising issues about their health and wellness. The concept of "justifying wellness" is extended by attending to how cancer patients utilize humor and laughter when trying to convince physicians that they are not sick but well. These instances of humor and laughter involve delicate discussions about weight, the use of sarcasm, and language designed to minimize sickness and optimize wellness. Attention is also given to how providers respond to patient-initiated humor and laughter. Key Words: laughter, humor, justifying wellness, oncology.