First, I would like to thank my advisor Dr. Michael J. Heller. It has been an honor to study in his research group. I appreciate his guidance and support not only in my research but also in my PhD life. I appreciate all his contributions of research idea and financial support to make my PhD experience productive. The joy and enthusiasm he has for the research was contagious and motivational for me, even during tough times in my PhD pursuit. I would like to thank the committee members, Professor Jan Talbot, Professor Xiahua Huang, Professor Kee Moon, and Dr. Parag Katira. Their advice and comments helped keep me motivated in my research. Chapter 3 is the reprint of some material currently being prepared for submission as it appears in Golkar Narenji, A., Heller, M., Efficient long-range fluorescence energy transfer in multiple donor single acceptor insulated DNA Nano construction. The author is the primary researcher/author of this work.