Cancer is a global health issue that affects mostly developed countries. Studies have shown that race is considered to be one of the risk factors for the development of cancer in the United States. Studies on the Differential Expression Analysis of RNA-seq and Microarray data show that genes are differentially expressed among African Americans (AA) and Caucasian Americans (CA). In our study, we are interested in performing a Differential Expression Analysis of RNA-seq data from a publicly available database. We are interested in looking at the immune pathways that are different between AA and CA patients, as we know that immunity has a major role to play in the development of tumor and in cancer progression. Since previous studies were done on a limited number of samples and on a single cancer type among AA and CA, we hypothesize that, increasing the sample size by including more than one type of adenocarcinoma cancer (colon and breast) might give new insights in terms of novel immune pathways and networks shared among the cancer types that are different by race. Differential expression and downstream analyses had resulted in six most significant up-regulated immune pathways in CA over AA patients in the colon cancer dataset. For breast cancer, six immune pathways for both the up- and down-regulated immune genes resulted in CA versus AA patients. CXCL10 and CD36 were seen to be the highly differentially expressed immune gene in CA over AA patients of colon and breast cancer dataset respectively. HLA-DPA1 was seen to be up-regulated in CA patients in both colon and breast cancer, potentially acting as a biomarker for gene expression differences seen in CA and AA. Two pathways, antigen processing and presentation pathway and proteasome pathway were seen in common between colon and breast cancer, but differed in terms of regulation, where they are up-regulated in colon and down-regulated in breast cancer CA patients. This contrast in regulation of the pathways between colon and breast may be possibly due to the heterogeneity associated with the cancer type, as both colon and breast cancer are heterogeneous in nature.