African American men are at higher risk of prostate cancer (PCa) compared to Non-African American men. This study identified health disparities such as socioeconomic status, education, and access to healthcare that may explain why African American men are more susceptible to this disease as well as what is being done to mitigate these barriers. A search was conducted to explore literature regarding health disparities African American men face pertaining to PCa. These articles were found using PubMed/MEDLINE, CINAHL, PsycINFO, and ERIC. Key search terms included: prostate cancer, African American men, screening, and health promotion. Year constraints were not used in the search. Reference lists were used to identify other sources from core articles. In this literature search, 35 articles were identified based on relevant titles. After reviewing each abstract, 15 articles were not relevant to the topic of interest and were discarded from the review. 20 articles were selected for a thorough review. The selected articles identified the health disparities and barriers contributing to the lack of knowledge and inaccurate beliefs pertaining to prostate cancer in African American men. Several studies indicated that African American men were less knowledgeable about the importance of early screening for PCa detection, despite African American men being at higher risk for PCa than men of other racial/ethnic groups. Studies identified the need for educational programs and interventions to encourage African American men to make more informed decisions regarding PCa screenings for early detection. Results showed a growing need for healthcare providers to encourage conversations with African American men regarding the important pros and cons of PCa screening. In summary, many African American men were unaware of their increased risk of PCa and did not have the knowledge to make informed decisions regarding early detection screening.