Background: In the United States, electronic cigarettes (e-cigarettes) are increasingly becoming popular among college students. E-cigarette users have been shown to be twice as likely to report signs of depression compared to non-users, with the majority of the population between ages 18-30. In this analysis, we compared differences in vapers’ and non-vapers' self-reported perceptions of their own health. Methods: In an ongoing 3-month pilot study at San Diego State University, participants, at least 18 years of age were recruited as a vaper and non-vapor, forming a dyad. Recruitment occurred via fliers, posters, referrals, and emails where students scanned a QR code to determine eligibility. At the first monthly visit, participants were given silicone wristbands to wear continuously for seven days. At the second visit, dyads took a survey, and returned the wristbands for nicotine analysis. Twelve eligible participants, six vapers and six non-vapers, who completed two months of the study, were evaluated for perception of their overall health. Results: Among the 6 vapers, 67% (n=4) self-reported their overall health as “good” and 33% (n=2) reported their health as “fair.” By month two, health perception among vapers decreased 17% (n=1) as 50% (n=3) reported their health as “fair.” Among the 6 non-vapers, 83% (n=5) reported their health to be at least “good” and 17% (n=1) reported their health as “fair.” By month two, health perception increased 17% (n=1) as all non-vapers reported their health to be at least “good.” By month two, 50% (n=3) of vapers felt depressed, and 67% (n=4) reported feeling tired in a short amount of time. Contrastingly, all non-vapers did not feel depressed at all and only 17% (n=1) felt tired. Conclusions: In this analysis, vapers’ perception of their own overall health followed a downward trend; they also had more reports of feeling tired and depressed. Non-vapers had a healthier perception of their own health compared to vapers overall. The use of e-cigarettes may affect how someone views their own health, therefore more research is required to strengthen this association given the pilot nature of this work.