Aphasia is a condition resulting from stroke that impairs individual’s communicative abilities. There are currently one million individuals living with aphasia in the US and within this population many have sentence comprehension impairments. This dissertation aims to investigate (1) approaches with which sentence comprehension impairment can be mitigated in individuals with aphasia, and (2) whether the integrity of connectivity between frontal and temporo-parietal regions is predictive of individuals’ sensitivity to the proposed mitigation approaches. Overall, the data in the current dissertation revealed that reducing the interference level via semantic cues can benefit the real-time sentence processing in individuals with aphasia. Moreover, there is an emerging pattern for the functional role of the anterior segment of the arcuate fasciculus and frontal aslant tract in the left hemisphere regarding real-time sensitivity to semantic cues during sentence comprehension.