The communication interfaces had concentrated onto delivering more data in a certain bandwidth until the biomedical application became hot topic in the research field. Today, the critical point of view for researcher is to develop a biomedical application that requires a low power consumption for various reasons. This revolution in the communication field attracts the researchers to develop a Brain-Computer Interface. The aim of this thesis is to address and test the data rate of Bluetooth and Enhanced ShockBurst protocol that are provided by nRF51822 from "Nordic Semiconductor" in the designed Brain-Computer Interface. For this reason, two experimental setups have been performed, with the aim of addressing throughput rate. The Bluetooth Smart has been implemented to wearable devices that has physiological sensors due to Bluetooth is commonly used protocol. By using the Bluetooth Smart protocol, the designed system has achieved 65 kbps for the throughput. The Enhanced ShockBurst protocol has been used to increase the throughput for the laboratory based research. By using Enhanced ShockBurst protocol, the designed system has achieved 183kbps. The results of the experiment show that Enhanced ShockBurst protocol is well suited to transmitting the data from the physiological sensors to receiver machine.