Purpose: Alzheimer’s disease (AD) is a neurodegenerative disease that results in progressive deficits in memory and cognitive skills. Decline in olfaction occurs in 85-90% of AD cases and can be detected preclinically. The earliest evidence of tau pathology in AD appears in the locus coeruleus (LC). Decreased LC integrity has been linked to olfactory dysfunction in rodents and cognitive impairment. The apolipoprotein-E (ApoE ε4 allele) is the strongest genetic predictor for developing AD. This study evaluated olfactory performance and LC integrity in non-demented older adults in the context of ApoE ε4 status. Participants: This study used archival data from one study in males ages 67-72 years (n = 228). Exploratory analyses included data from a second study (n = 21; 47.6% female) ages 74-87 years. Methodology: Archival data from two studies were examined separately to assess the relationship between olfaction and LC signal intensity. Participants in the first study completed the San Diego Odor Identification Task (SDOID) and an LC scan. Linear regressions investigated the relationship between LC integrity and SDOID, as well as in ApoE ε4 positive and ε4 negative groups separately. Participants in the second study completed the SDOID, Alzheimer’s Disease Assessment Scale-Cognitive Subscale with Odor-place Association (ADAS-Cog Odor), an odor-based remote memory task, an odor recognition memory task, and an LC scan. Linear regressions examined the relationship between LC integrity and each odor task performance overall and in ApoE ε4+ and ε4- groups separately. Analyses of covariance (ANCOVAs) assessed differences between ApoE ε4+ and ε4- groups on odor assessments and LC signal intensity in each dataset. Results: ApoE ε4+ participants in the first study demonstrated a positive relationship between SDOID and LC signal intensity. These results were replicated in the second study in which SDOID significantly predicted LC signal intensity in ε4+ participants. Odor remote and recognition memory significantly predicted LC signal intensity in ε4+ participants. Conclusions: Odor identification, remote, and recognition memory significantly predicted LC signal intensity in ApoE ε4+ participants. These results suggest that incorporating odor identification, remote memory, and recognition memory into standard neuropsychological batteries could identify those at risk for conversion to AD.