Clinical data management systems are becoming increasingly valuable clinical trials of all types. Capturing numerous data elements in a reproducible and replicable with standardized sets of data elements and workflows is essential to successful clinical trials. In this thesis, three clinical data management systems (REDCap, OpenClinica, and a custom built application) are compared and evaluated along seven major categories: (1) interoperability; (2) data management; (3) workflow management; (4) security and compliances; (5) licensing; (6) community; and (7) system requirements; This evaluation provides background for making an informed decision among clinical data management system platforms for the needs of clinical research across the aforementioned seven categories, which span the key elements of clinical data management systems